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All of the active B12 group reporting showed reduction in severity of symptoms ranging treating sports injuries from sports 31% to 70%, while the placebo controls reported either no change or a worsening of symptoms. wilcoxon-rank of .002 for the end-points of sneezing, nasal congestion and injuries runny nose; and p = .005 for ige reductions. in 1992, the above mentioned data from 1988 on were presented by dr. o''connor to the fda. treating and sports the fda panel acknowledged the safety of injuries the treatment. treating the panel seemed to be in agreement that the statistics indicated a significant reduction in ige and that a quantitative drop in symptoms was demonstrated. in 1992, belen anibarro, md, studied five sports and injuries children with asthma with metabisulfite intolerance confirmed by oral challenge testing. the test was repeated after premedication with 1.5 mg of oral cyanocobalamin. in four treating of the five patients sports treated, bronchospasm did not develop in the second injuries and treating metabisulfite challenge.6

in 1990 study in san diego, ca the 5 active subjects with allergic rhinitis had a lowered total serum ige from day 0 to day 90 while 4 placebo subjects, sports (2 with allergic rhinitis, 1 with asthma and 1 with injuries and treating both), had flat or increased sports ige levels.4 in a randomized, double-blind, placebo controlled study of symptoms injuries and serum treating ige levels in san diego, ca in mid-1991, subjects had allergic sports rhinitis and/or injuries asthma. serum was drawn treating at day 0 and day 30. sports seven of the 10 active treated subjects had a reduction in total serum ige levels. in 10 placebo injuries treated treating subjects, sports 5 had levels injuries of total serum ige that stayed the same (plus or minus treating 5%), 3 decreased and 2 increased.5 statistical analysis of the open-label sports study as well as the double-blind randomized placebo controlled study have shown a significant effect of vitamin b12 in lowering serum ige concentrations injuries.